Diagnostic testing that indicates biological age

Best Diagnostic Tests

Inflammation markers

Interleukin-6 (IL-6)

IL-6 as a prediction for the diseases of aging

For mitochondrial health    → Correia-Melo C 2016

For immune and auto-immune disease   → Astrakhantseva IV 2004

For heart disease   →  Ridker P 2000

For stroke    → Herder C 2011

For kidney disease    → Lee B 2015

For Alzheimer’s disease    → Butchart J 2015 & Holmes C 2011

For defense against bacteria   → Puchta A 2016

For defense against viruses  → McElroy AK 2016

For intelligence → Bettcher B 2014 (multiple) 2015

For sleep disorders   → Irwin MR 2015

For physical performance  → Cesari M 2004

IL-6 for longevity and all-cause mortality

Puzianowska-Kuznicka M 2016 & Arai Y 2015 & Varadhan R 2014 & Lee JK 2012 &  Derhovanessian E 2010 & Bruunsgaard H 2003 & Reuben DB 2002 & Taaffe DR 2000

Also grouped with the IL-6 test in Arai Y 2015 are

Tumor necrosis factor Alpha (TNF-α)

hsCRP

CMV-IgG

Up and coming diagnostic tests for biological age that show great promise

DNA methylation (“clock”) (epigenome)  →  Horvath S. 2013 & Hannun G 2013

Transcriptome (“clock”)  → Peters MJ 2015 & Timmons JA

Nucleolar size  →  Buchwalter A (2017 lecture)

Slow wave sleep during first non-REM   →  Mander BA 2017

Structural MRI of brain →   Cole JH 2017

Other diagnostic tests that have shown correlation to biological age

Proteome (Circulating Protein “clock”)  →  Enroth S 2015

Chaparome     →  Labbadia J 2015

DNA breakage

NAD+  →  Guarente L 2016

CD-38  →  Camacho-Pereira J 2016

H2S   →  Perridon BW 2016

GSH/GSSG →  Sies H 2015

Cysteine/Cystine   →  Sies H 2015

Telomere length  →  Blackburn E 2016

Heart rate variability   →  Kurita A 2013

Ability to smell  →  Devanand DP 2015

Tests you can do at home

Getting off the floor (touches needed)  →  Araujo CG 2012

Static balance  (seconds on one foot)   →  Whitacker Wellness Institute

Skin elasticity (pull, then time to normal)  →  Whitacker Wellness Institute

Catching ruler (after unexpectant drop) →  Whitacker Wellness Institute

Lung function (blowing out match at distance) →  Whitacker Wellness Institute

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