References

Abdelmohsen, K., R. Pullmann, Jr., A. Lal, H. H. Kim, S. Galban, X. Yang, J. D. Blethrow, M. Walker, J. Shubert, D. A. Gillespie, H. Furneaux and M. Gorospe (2007). “Phosphorylation of HuR by Chk2 regulates SIRT1 expression.” Mol Cell 25(4): 543-557.

Adebanjo, O.A. Annandatheerthavarada, Koval, Moonga, Biswas, Sun, Sodam, Bevis, Huang, Epstein, Lai, Avadhani, Zaidi. (1999) A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis.

Albrecht, S. C., A. G. Barata, J. Grosshans, A. A. Teleman and T. P. Dick (2011). “In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis.” Cell Metab 14(6): 819-829.

Alic N, Partridge L. Myc mouse and anti-ageing therapy. Trends Endocrinol Metab. 2015;26(4):163-4.

Armah CN, Traka MH, Dainty JR, Defernez M, Janssens A, Leung W, et al. A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function. Am J Clin Nutr. 2013;98(3):712-22.

Astrakhantseva IV, Efimov GA, Drutskaya MS, Kruglov AA, Nedospasov SA. Modern anti-cytokine therapy of autoimmune diseases. Biochemistry (Mosc). 2014;79(12):1308-21.

Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 2011;13(4):461-8.

Barr, L. A. and J. W. Calvert (2014). “Discoveries of Hydrogen Sulfide as a Novel Cardiovascular Therapeutic.” Circulation Journal 78(9): 2111-2118.

Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics. 2005;85(2):258-63.

Belsky, D. W., A. Caspi, R. Houts, H. J. Cohen, D. L. Corcoran, A. Danese, H. Harrington, S. Israel, M. E. Levine, J. D. Schaefer, K. Sugden, B. Williams, A. I. Yashin, R. Poulton and T. E. Moffitt (2015). “Quantification of biological aging in young adults.” Proc Natl Acad Sci U S A 112(30): E4104-4110.

Ben Mosbah, I., Y. Mouchel, J. Pajaud, C. Ribault, C. Lucas, A. Laurent, K. Boudjema, F. Morel, A. Corlu and P. Compagnon (2012). “Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat.” PLoS One 7(11): e50235.

Bettcher BM, Kramer JH. Longitudinal inflammation, cognitive decline, and Alzheimer’s disease: a mini-review. Clin Pharmacol Ther. 2014;96(4):464-9.

Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, et al. Interleukin-6, age, and corpus callosum integrity. PLoS One. 2014;9(9):e106521.

Bettcher BM, Yaffe K, Boudreau RM, Neuhaus J, Aizenstein H, Ding J, et al. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging. 2015;36(2):948-54.

Bai, P. and C. Canto (2012). “The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease.” Cell Metab 16(3): 290-295.

Balogun, E., M. Hoque, P. Gong, E. Killeen, C. J. Green, R. Foresti, J. Alam and R. Motterlini (2003). “Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.” Biochem J 371(Pt 3): 887-895.

Barata H, Thompson M, Zielinska W, Han YS, Mantilla CB, Prakash YS, et al. The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology. 2004;145(2):881-9.

Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, et al. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012;487(7405):114-8.

Ame, J. C., V. Rolli, V. Schreiber, C. Niedergang, F. Apiou, P. Decker, S. Muller, T. Hoger, J. Menissier-de Murcia and G. de Murcia (1999). “PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.” J Biol Chem 274(25): 17860-17868.

Arai, Y., C. M. Martin-Ruiz, M. Takayama, Y. Abe, T. Takebayashi, S. Koyasu, M. Suematsu, N. Hirose and T. von Zglinicki (2015). “Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians.” EBioMedicine.

Bocklandt, S., W. Lin, M. E. Sehl, F. J. Sanchez, J. S. Sinsheimer, S. Horvath and E. Vilain (2011). “Epigenetic predictor of age.” PLoS One 6(6): e14821.

Bos, E. M., R. Wang, P. M. Snijder, M. Boersema, J. Damman, M. Fu, J. Moser, J. L. Hillebrands, R. J. Ploeg, G. Yang, H. G. Leuvenink and H. van Goor (2013). “Cystathionine gamma-lyase protects against renal ischemia/reperfusion by modulating oxidative stress.” J Am Soc Nephrol 24(5): 759-770.

Braidy, N., G. J. Guillemin and R. Grant (2011). “Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons.” Int J Tryptophan Res 4: 29-37.

Braidy, N., G. J. Guillemin, H. Mansour, T. Chan-Ling, A. Poljak and R. Grant (2011). “Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats.” PLoS One 6(4): e19194.

Butchart J. Etanercept in Alzheimer disease. 2015.

Calvert, J. W., M. Elston, C. K. Nicholson, S. Gundewar, S. Jha, J. W. Elrod, A. Ramachandran and D. J. Lefer (2010). “Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice.” Circulation 122(1): 11-19.

Calvert, J. W., S. Jha, S. Gundewar, J. W. Elrod, A. Ramachandran, C. B. Pattillo, C. G. Kevil and D. J. Lefer (2009). “Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.” Circ Res 105(4): 365-374.

Canto, C., A. A. Sauve and P. Bai (2013). “Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.” Mol Aspects Med 34(6): 1168-1201.

Cao Z, Tsang M, Zhao H, Li Y. Induction of endogenous antioxidants and phase 2 enzymes by α-lipoic acid in rat cardiac H9C2 cells: protection against oxidative injury. Biochemical and Biophysical Research Communications. 2003;310(3):979-85.

Cardus A, Uryga AK, Walters G, Erusalimsky JD. SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res. 2013;97(3):571-9.

Cesari M. Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study. 2004.

Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 2014;20(6):991-1005.

Chen S, Seiler J, Santiago-Reichelt M, Felbel K, Grummt I, Voit R. Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. Mol Cell. 2013;52(3):303-13.

Chen, D., J. Bruno, E. Easlon, S. J. Lin, H. L. Cheng, F. W. Alt and L. Guarente (2008). “Tissue-specific regulation of SIRT1 by calorie restriction.” Genes Dev 22(13): 1753-1757.

Chen, Q., A. K. Camara, D. F. Stowe, C. L. Hoppel and E. J. Lesnefsky (2007). “Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.” Am J Physiol Cell Physiol 292(1): C137-147.

Cheng L. Resveratrol attenuates inflammation and oxidative stress induced by myocardialischemia-reperfusion injury: role of Nrf2/ARE pathway. 2015.

Cheng, Y., J. F. Ndisang, G. Tang, K. Cao and R. Wang (2004). “Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats.” Am J Physiol Heart Circ Physiol 287(5): H2316-2323.

Cho EH. SIRT3 as a Regulator of Non-alcoholic Fatty Liver Disease. J Lifestyle Med. 2014;4(2):80-5.

Chouliaras, L., D. L. van den Hove, G. Kenis, S. Keitel, P. R. Hof, J. van Os, H. W. Steinbusch, C. Schmitz and B. P. Rutten (2012). “Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction.” Neurobiol Aging 33(8): 1672-1681.

Coletta, C., A. Papapetropoulos, K. Erdelyi, G. Olah, K. Modis, P. Panopoulos, A. Asimakopoulou, D. Gero, I. Sharina, E. Martin and C. Szabo (2012). “Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation.” Proc Natl Acad Sci U S A 109(23): 9161-9166.

Colman, R. J., T. M. Beasley, J. W. Kemnitz, S. C. Johnson, R. Weindruch and R. M. Anderson (2014). “Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.” Nat Commun 5: 3557.

Cremers, C. M. and U. Jakob (2013). “Oxidant sensing by reversible disulfide bond formation.” J Biol Chem 288(37): 26489-26496. Cyclization, Hydrolysis, and Base-Exchange Chemistries. 1998.

De Haes, W., L. Frooninckx, R. Van Assche, A. Smolders, G. Depuydt, J. Billen, B. P. Braeckman, L. Schoofs and L. Temmerman (2014). “Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.” Proc Natl Acad Sci U S A 111(24): E2501-2509.

Deaglio S, Vaisitti T, Billington R, Bergui L, Omede P, Genazzani AA, et al. CD38/CD19: a lipid raft-dependent signaling complex in human B cells. Blood. 2007;109(12):5390-8.

Derhovanessian, E., A. B. Maier, R. Beck, G. Jahn, K. Hahnel, P. E. Slagboom, A. J. de Craen, R. G. Westendorp and G. Pawelec (2010). “Hallmark features of immunosenescence are absent in familial longevity.” J Immunol 185(8): 4618-4624.

Dinkova-Kostova AT, Abramov AY. The emerging role of Nrf2 in mitochondrial function. Free Radic Biol Med. 2015;88(Pt B):179-88.

Dinkova-Kostova, A. T., K. T. Liby, K. K. Stephenson, W. D. Holtzclaw, X. Gao, N. Suh, C. Williams, R. Risingsong, T. Honda, G. W. Gribble, M. B. Sporn and P. Talalay (2005). “Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.” Proc Natl Acad Sci U S A 102(12): 4584-4589.

Dipp M. Cyclic ADP-Ribose Is the Primary Trigger for Hypoxic Pulmonary Vasoconstriction in the Rat Lung In Situ. 2001.

Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V, Zhang J. KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem J. 2015;469(3):347-55.

Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, et al. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011;334(6057):806-9.

Escande C. Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38. 2013.

Fernandez, A. F., G. F. Bayon, R. G. Urdinguio, E. G. Torano, M. G. Garcia, A. Carella, S. Petrus-Reurer, C. Ferrero, P. Martinez-Camblor, I. Cubillo, J. Garcia-Castro, J. Delgado-Calle, F. M. Perez-Campo, J. A. Riancho, C. Bueno, P. Menendez, A. Mentink, K. Mareschi, F. Claire, C. Fagnani, E. Medda, V. Toccaceli, S. Brescianini, S. Moran, M. Esteller, A. Stolzing, J. de Boer, L. Nistico, M. A. Stazi and M. F. Fraga (2015). “H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells.” Genome Res 25(1): 27-40.

Ferrero E, Malavasi, F., (1999) The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38.

Fifel K. Sirtuin 3: a molecular pathway linking sleep deprivation to neurological diseases. J Neurosci. 2014;34(28):9179-81.

Fiorucci S, Distrutti E, Cirino G, Wallace JL. The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Gastroenterology. 2006;131(1):259-71.

Flier J, Van Muiswinkel FL, Jongenelen CA, Drukarch B. The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells. Free Radic Res. 2002;36(6):695-9.

Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 2006;20(9):1075-80.

Ford, J., S. Ahmed, S. Allison, M. Jiang and J. Milner (2014). “JNK2-dependent regulation of SIRT1 protein stability.” Cell Cycle 7(19): 3091-3097.

Forman, H. J., J. M. Fukuto, T. Miller, H. Zhang, A. Rinna and S. Levy (2008). “The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.” Arch Biochem Biophys 477(2): 183-195.

Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-9.

Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128(1):92-105.

Franceschi C. Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured? Nutrition Reviews. 2007;65(12):173-6.

Fu, M., W. Zhang, L. Wu, G. Yang, H. Li and R. Wang (2012). “Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production.” Proc Natl Acad Sci U S A 109(8): 2943-2948.

Functional Decline in High-Functioning Community-Dwelling Older Persons. 2002.

Fusco S, Leone L, Barbati SA, Samengo D, Piacentini R, Maulucci G, et al. A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability. Cell Rep. 2016;14(5):1195-205.

Ge Y, Jiang W, Gan L, Wang L, Sun C, Ni P, et al. Mouse embryonic fibroblasts from CD38 knockout mice are resistant to oxidative stresses through inhibition of reactive oxygen species production and Ca(2+) overload. Biochem Biophys Res Commun. 2010;399(2):167-72.

Ge, S. N., M. M. Zhao, D. D. Wu, Y. Chen, Y. Wang, J. H. Zhu, W. J. Cai, Y. Z. Zhu and Y. C. Zhu (2014). “Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na(+)/K(+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats.” Antioxid Redox Signal 21(15): 2061-2082.

Gegotek A, Skrzydlewska E. The role of transcription factor Nrf2 in skin cells metabolism. Arch Dermatol Res. 2015;307(5):385-96.

Geng, B., H. Yan, G. Z. Zhong, C. Y. Zhang, X. B. Chen, H. F. Jiang, C. S. Tang and J. B. Du (2004). “[Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor].” Beijing Da Xue Xue Bao 36(1): 106.

Gerhart-Hines Z, Dominy JE, Jr., Blattler SM, Jedrychowski MP, Banks AS, Lim JH, et al. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell. 2011;44(6):851-63.

Giralt A, Villarroya F. SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging. Biochem J. 2012;444(1):1-10.

Givvimani, S., C. Munjal, R. Gargoum, U. Sen, N. Tyagi, J. C. Vacek and S. C. Tyagi (2011). “Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure.” J Appl Physiol (1985) 110(4): 1093-1100.

Goel, A., D. R. Spitz and G. J. Weiner (2012). “Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma.” J Cell Biochem 113(2): 419-425.

Gomes P, Outeiro TF, Cavadas C. Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism. Trends Pharmacol Sci. 2015;36(11):756-68.

Gomes, A. P., N. L. Price, A. J. Ling, J. J. Moslehi, M. K. Montgomery, L. Rajman, J. P. White, J. S. Teodoro, C. D. Wrann, B. P. Hubbard, E. M. Mercken, C. M. Palmeira, R. de Cabo, A. P. Rolo, N. Turner, E. L. Bell and D. A. Sinclair (2013). “Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.” Cell 155(7): 1624-1638.

Goodson NJ, Symmons DP, Scott DG, Bunn D, Lunt M, Silman AJ. Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year follow up study of a primary care-based inception cohort. Arthritis Rheum. 2005;52(8):2293-9.

Grob A, Roussel P, Wright JE, McStay B, Hernandez-Verdun D, Sirri V. Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sci. 2009;122(Pt 4):489-98.

Grozio A, Sociali G, Sturla L, Caffa I, Soncini D, Salis A, et al. CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. J Biol Chem. 2013;288(36):25938-49.

Guarente L. The many faces of sirtuins: Sirtuins and the Warburg effect. Nat Med. 2014;20(1):24-5.

Guarente, L. (2000). “Sir2 links chromatin silencing, metabolism, and aging.” Genes Dev 14(9): 1021-1026.

Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006;126(5):941-54.

Halaschek-Wiener J, Amirabbasi-Beik M, Monfared N, Pieczyk M, Sailer C, Kollar A, et al. Genetic variation in healthy oldest-old. PLoS One. 2009;4(8):e6641.

Han L, Ge J, Zhang L, Ma R, Hou X, Li B, et al. Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte. Sci Rep. 2015;5:15366.

Harman D. AGING: A THEORY BASED ON FREE RADICAL AND RADIATION CHEMISTRY. 1958.

He, C. and D. J. Klionsky (2009). “Regulation mechanisms and signaling pathways of autophagy.” Annu Rev Genet 43: 67-93.

He, H. J., G. Y. Wang, Y. Gao, W. H. Ling, Z. W. Yu and T. R. Jin (2012). “Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.” World J Diabetes 3(5): 94-104.

Hill, B. C., T. C. Woon, P. Nicholls, J. Peterson, C. Greenwood and A. J. Thomson (1984). “Interactions of sulphide and other ligands with cytochrome c oxidase. An electron-paramagnetic-resonance study.” Biochem J 224(2): 591-600.

Hinson, J. A., D. W. Roberts and L. P. James (2010). “Mechanisms of acetaminophen-induced liver necrosis.” Handb Exp Pharmacol(196): 369-405.

Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010;464(7285):121-5.

Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:267-77.

Hoffman-Liebermann B. Interleukin-6- and Leukemia Inhibitory Factor-Induced Terminal Differentiation of Myeloid Leukemia Cells Is Blocked at an Intermediate Stage by Constitutive c-myc. 1991.

Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K. Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. J Appl Physiol (1985). 2010;109(2):332-40.

Holmes C, Butchart J. Systemic inflammation and Alzheimer’s disease. Biochem Soc Trans. 2011;39(4):898-901.

Horvath, S. (2013). “DNA methylation age of human tissues and cell types.” Genome Biol 14(10): R115.

Horvath, S. (2015). “Erratum to: DNA methylation age of human tissues and cell types.” Genome Biol 16: 96.

Horvath, S., V. Mah, A. T. Lu, J. S. Woo, O. W. Choi, A. J. Jasinska, J. A. Riancho, S. Tung, N. S. Coles, J. Braun, H. V. Vinters and L. S. Coles (2015). “The cerebellum ages slowly according to the epigenetic clock.” Aging (Albany NY) 7(5): 294-306.

Huang Y, Li W, Su ZY, Kong AN. The complexity of the Nrf2 pathway: beyond the antioxidant response. J Nutr Biochem. 2015;26(12):1401-13.

Hussain A. Functional Expression of Secreted Mouse BST-1 in Yeast1. 1998.

Imai, S. (2009). “SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty.” Curr Opin Clin Nutr Metab Care 12(4): 350-356.

Insko, M. A., T. L. Deckwerth, P. Hill, C. F. Toombs and C. Szabo (2009). “Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide.” Br J Pharmacol 157(6): 944-951.

Ise F, Takasuka H, Hayashi S, Takahashi K, Koyama M, Aihara E, et al. Stimulation of duodenal HCO(3)(-) secretion by hydrogen sulphide in rats: relation to prostaglandins, nitric oxide and sensory neurones. Acta Physiol (Oxf). 2011;201(1):117-26.

Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013;39(2):311-23.

Jackson, M. J. (2011). “Control of reactive oxygen species production in contracting skeletal muscle.” Antioxid Redox Signal 15(9): 2477-2486.

Jain, S. K., J. Rains, J. Croad, B. Larson and K. Jones (2009). “Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.” Antioxid Redox Signal 11(2): 241-249.

Jiang, H. L., H. C. Wu, Z. L. Li, B. Geng and C. S. Tang (2005). “[Changes of the new gaseous transmitter H2S in patients with coronary heart disease].” Di Yi Jun Yi Da Xue Xue Bao 25(8): 951-954.

Jin, H. F., J. B. Du, X. H. Li, Y. F. Wang, Y. F. Liang and C. S. Tang (2006). “Interaction between hydrogen sulfide/cystathionine gamma-lyase and carbon monoxide/heme oxygenase pathways in aortic smooth muscle cells.” Acta Pharmacol Sin 27(12): 1561-1566.

Jodar, L., E. M. Mercken, J. Ariza, C. Younts, J. A. Gonzalez-Reyes, F. J. Alcain, I. Buron, R. de Cabo and J. M. Villalba (2011). “Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts.” J Gerontol A Biol Sci Med Sci 66(3): 247-256.

Jung, K. J., A. Dasgupta, K. Huang, S. J. Jeong, C. Pise-Masison, K. V. Gurova and J. N. Brady (2008). “Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells.” J Virol 82(17): 8537-8547.

Jung, S. B., C. S. Kim, Y. R. Kim, A. Naqvi, T. Yamamori, S. Kumar, A. Kumar and K. Irani (2013). “Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.” PLoS One 8(6): e65415.

Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature. 2012;483(7388):218-21.

Kang B. Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression. 2008.

Kaspar, J. W., S. K. Niture and A. K. Jaiswal (2012). “Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.” J Cell Sci 125(Pt 4): 1027-1038.

Kasparek MS, Linden DR, Kreis ME, Sarr MG. Gasotransmitters in the gastrointestinal tract. Surgery. 2008;143(4):455-9.

Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H. Flavonoids as inhibitors of human CD38. Bioorg Med Chem Lett. 2011;21(13):3939-42.

Kennedy, S. R., L. A. Loeb and A. J. Herr (2012). “Somatic mutations in aging, cancer and neurodegeneration.” Mech Ageing Dev 133(4): 118-126.

Kida, K., E. Marutani, R. K. Nguyen and F. Ichinose (2015). “Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice.” Nitric Oxide 46: 87-92.

Kida, K., M. Yamada, K. Tokuda, E. Marutani, M. Kakinohana, M. Kaneki and F. Ichinose (2011). “Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson’s disease.” Antioxid Redox Signal 15(2): 343-352.

Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell. 2011;20(4):487-99.

Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell. 2006;23(4):607-18.

Kimura S, Warabi E, Yanagawa T, Ma D, Itoh K, Ishii Y, et al. Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009;387(1):109-14.

Kimura, Y. and H. Kimura (2004). “Hydrogen sulfide protects neurons from oxidative stress.” FASEB J 18(10): 1165-1167.

Kincaid B, Bossy-Wetzel E. Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci. 2013;5:48.

Kirkwood T. Evolution of senescence: late survival sacrificed for reprodution. 1991.

Kirkwood, T. B. (2005). “Understanding the odd science of aging.” Cell 120(4): 437-447.

Kirkwood, T. L., P. Kapahi and D. P. Shanley (2000). “Evolution, stress, and longevity.” J Anat 197 Pt 4: 587-590.

Kitada, M., S. Kume, N. Imaizumi and D. Koya (2011). “Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway.” Diabetes 60(2): 634-643.

Kondo, K., S. Bhushan, A. L. King, S. D. Prabhu, T. Hamid, S. Koenig, T. Murohara, B. L. Predmore, G. Gojon, Sr., G. Gojon, Jr., R. Wang, N. Karusula, C. K. Nicholson, J. W. Calvert and D. J. Lefer (2013). “H(2)S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase.” Circulation 127(10): 1116-1127.

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, et al. Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One. 2010;5(7):e11707.

Kugel S, Mostoslavsky R. Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci. 2014;39(2):72-81.

Kumar, S. and A. K. Pandey (2013). “Chemistry and biological activities of flavonoids: an overview.” ScientificWorldJournal 2013: 162750.

Kumasaka, S. Shoji,H. Okabe, E (1999) Novel Mechanisms Involved in Superoxide Anion Radcal-Triggered Ca2+ Release from Cardiac Sarcoplasmic Reticulum Linked to Cyclic ADP-Ribose Stimulation.

Labbadia, J. and R. I. Morimoto (2015). “The biology of proteostasis in aging and disease.” Annu Rev Biochem 84: 435-464.

Lagouge, M., C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Geny, M. Laakso, P. Puigserver and J. Auwerx (2006). “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.” Cell 127(6): 1109-1122.

Landis, G. N., M. P. Salomon, D. Keroles, N. Brookes, T. Sekimura and J. Tower (2015). “The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila.” Aging (Albany NY) 7(1): 53-69.

Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013;50(5):686-98.

Lee BT, Ahmed FA, Hamm LL, Teran FJ, Chen CS, Liu Y, et al. Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease. BMC Nephrol. 2015;16:77.

Lee CU, Song EK, Yoo CH, Kwak YK, Han MK. Lipopolysaccharide induces CD38 expression and solubilization in J774 macrophage cells. Mol Cells. 2012;34(6):573-6.

Lee JK, Bettencourt R, Brenner D, Le TA, Barrett-Connor E, Loomba R. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS One. 2012;7(4):e34218.

Lee S, Paudel O, Jiang Y, Yang XR, Sham JS. CD38 mediates angiotensin II-induced intracellular Ca(2+) release in rat pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol. 2015;52(3):332-41.

Lee, Z. W., J. Zhou, C. S. Chen, Y. Zhao, C. H. Tan, L. Li, P. K. Moore and L. W. Deng (2011). “The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.” PLoS One 6(6): e21077.

Leruez S, Milea D, Defoort-Dhellemmes S, Colin E, Crochet M, Procaccio V, et al. Sensorineural hearing loss in OPA1-linked disorders. Brain. 2013;136(Pt 7):e236.

Li, L., M. Whiteman, Y. Y. Guan, K. L. Neo, Y. Cheng, S. W. Lee, Y. Zhao, R. Baskar, C. H. Tan and P. K. Moore (2008). “Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.” Circulation 117(18): 2351-2360.

Liu GH, Qu J, Shen X. NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta. 2008;1783(5):713-27.

Liu R, Dang W, Du Y, Zhou Q, Jiao K, Liu Z. SIRT2 is involved in the modulation of depressive behaviors. Sci Rep. 2015;5:8415.

Liu R, Liu H, Ha Y, Tilton RG, Zhang W. Oxidative stress induces endothelial cell senescence via downregulation of Sirt6. Biomed Res Int. 2014;2014:902842.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27(24):8807-14.

Long AN, Owens K, Schlappal AE, Kristian T, Fishman PS, Schuh RA. Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model. BMC Neurol. 2015;15:19.

Lupoli, R., A. Di Minno, G. Spadarella, M. Franchini, R. Sorrentino, G. Cirino and G. Di Minno (2015). “Methylation reactions, the redox balance and atherothrombosis: the search for a link with hydrogen sulfide.” Semin Thromb Hemost 41(4): 423-432.

Magesh, S., Y. Chen and L. Hu (2012). “Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents.” Med Res Rev 32(4): 687-726.

Marinho, H. S., C. Real, L. Cyrne, H. Soares and F. Antunes (2014). “Hydrogen peroxide sensing, signaling and regulation of transcription factors.” Redox Biol 2: 535-562.

Marioni, R. E., S. Shah, A. F. McRae, B. H. Chen, E. Colicino, S. E. Harris, J. Gibson, A. K. Henders, P. Redmond, S. R. Cox, A. Pattie, J. Corley, L. Murphy, N. G. Martin, G. W. Montgomery, A. P. Feinberg, M. D. Fallin, M. L. Multhaup, A. E. Jaffe, R. Joehanes, J. Schwartz, A. C. Just, K. L. Lunetta, J. M. Murabito, J. M. Starr, S. Horvath, A. A. Baccarelli, D. Levy, P. M. Visscher, N. R. Wray and I. J. Deary (2015). “DNA methylation age of blood predicts all-cause mortality in later life.” Genome Biol 16: 25.

Martin GR, McKnight GW, Dicay MS, Coffin CS, Ferraz JG, Wallace JL. Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract. Dig Liver Dis. 2010;42(2):103-9.

Massudi, H., R. Grant, N. Braidy, J. Guest, B. Farnsworth and G. J. Guillemin (2012). “Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.” PLoS One 7(7): e42357.

Mathias RA, Greco TM, Oberstein A, Budayeva HG, Chakrabarti R, Rowland EA, et al. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell. 2014;159(7):1615-25.

McCay C. THE EFFECT OF RETARDED GROWTH UPON THE LENGTH OF LIFE SPAN AND UPON THE ULTIMATE BODY SIZE Â. 1935.

McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482.

Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428-35.

Merino, M. M., C. Rhiner, J. M. Lopez-Gay, D. Buechel, B. Hauert and E. Moreno (2015). “Elimination of unfit cells maintains tissue health and prolongs lifespan.” Cell 160(3): 461-476.

Metes-Kosik, N., I. Luptak, P. M. Dibello, D. E. Handy, S. S. Tang, H. Zhi, F. Qin, D. W. Jacobsen, J. Loscalzo and J. Joseph (2012). “Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance.” Mol Nutr Food Res 56(12): 1812-1824.

Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008;452(7186):492-6.

Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-beta-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300(3):L391-401.

Mokni M, Elkahoui S, Limam F, Amri M, Aouani E. Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat. Neurochem Res. 2007;32(6):981-7.

Mokni, M., S. Hamlaoui, I. Karkouch, M. Amri, L. Marzouki, F. Limam and E. Aouani (2013). “Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities.” Iran J Pharm Res 12(4): 867-875.

Moriarty-Craige, S. E., K. N. Ha, P. Sternberg, Jr., M. Lynn, S. Bressler, G. Gensler and D. P. Jones (2007). “Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration.” Am J Ophthalmol 143(2): 206-211.

Moscardo A, Valles J, Latorre A, Jover R, Santos MT. The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function. J Thromb Haemost. 2015;13(7):1335-44.

Mustafa, A. K., G. Sikka, S. K. Gazi, J. Steppan, S. M. Jung, A. K. Bhunia, V. M. Barodka, F. K. Gazi, R. K. Barrow, R. Wang, L. M. Amzel, D. E. Berkowitz and S. H. Snyder (2011). “Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels.” Circ Res 109(11): 1259-1268.

Nallasamy, P., H. Si, P. V. Babu, D. Pan, Y. Fu, E. A. Brooke, H. Shah, W. Zhen, H. Zhu, D. Liu, Y. Li and Z. Jia (2014). “Sulforaphane reduces vascular inflammation in mice and prevents TNF-alpha-induced monocyte adhesion to primary endothelial cells through interfering with the NF-kappaB pathway.” J Nutr Biochem 25(8): 824-833.

Nathan, C. and A. Cunningham-Bussel (2013). “Beyond oxidative stress: an immunologist’s guide to reactive oxygen species.” Nat Rev Immunol 13(5): 349-361.

Neish AS, Jones RM. Redox signaling mediates symbiosis between the gut microbiota and the intestine. Gut Microbes. 2014;5(2):250-3.

Nie H. SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia. 2014.

Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev. 2012;92(3):1479-514.

Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, et al. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 2011;12(10):1069-76.

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014;33(13):1438-53.

Okabe E. (2000) C a l m o d u l i n a n d Cyclic A D P – R i b o s e Interaction in C a2 Signaling Related to C a r d i a c Sarcoplasmic Reticulum: S u p e r o x i d e A n i o n Radical-Triggered C a 2 + Release

Oliver, A. W., J. C. Ame, S. M. Roe, V. Good, G. de Murcia and L. H. Pearl (2004). “Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.” Nucleic Acids Res 32(2): 456-464.

Otto, H., P. A. Reche, F. Bazan, K. Dittmar, F. Haag and F. Koch-Nolte (2005). “In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs).” BMC Genomics 6: 139.

Pae, H. O., G. S. Jeong, S. O. Jeong, H. S. Kim, S. A. Kim, Y. C. Kim, S. J. Yoo, H. D. Kim and H. T. Chung (2007). “Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells.” Exp Mol Med 39(3): 267-277.

Palacios O. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC‐1α in skeletal muscle. 2009.

Pali M. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. 2015.

Pan, L. L., X. H. Liu, Q. H. Gong, D. Wu and Y. Z. Zhu (2011). “Hydrogen sulfide attenuated tumor necrosis factor-alpha-induced inflammatory signaling and dysfunction in vascular endothelial cells.” PLoS One 6(5): e19766.

Papapetropoulos, A., A. Pyriochou, Z. Altaany, G. Yang, A. Marazioti, Z. Zhou, M. G. Jeschke, L. K. Branski, D. N. Herndon, R. Wang and C. Szabo (2009). “Hydrogen sulfide is an endogenous stimulator of angiogenesis.” Proc Natl Acad Sci U S A 106(51): 21972-21977.

Paredes-Gonzalez X, Fuentes F, Jeffery S, Saw CL, Shu L, Su ZY, et al. Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. Biopharm Drug Dispos. 2015;36(7):440-51.

Paredes-Gonzalez X, Fuentes F, Su ZY, Kong AN. Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. AAPS J. 2014;16(4):727-35.

Paz JC, Park S, Phillips N, Matsumura S, Tsai WW, Kasper L, et al. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proc Natl Acad Sci U S A. 2014;111(48):17116-21.

Peake, B. F., C. K. Nicholson, J. P. Lambert, R. L. Hood, H. Amin, S. Amin and J. W. Calvert (2013). “Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner.” Am J Physiol Heart Circ Physiol 304(9): H1215-1224.

Pearl R. The form of the growth curve of the cantaloupe (Cucumis Melo) under field conditions.

Peng C. The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme. 2011.

Peris T. Middle-aged mothers live longer. 1997.

Polhemus, D. J. and D. J. Lefer (2014). “Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.” Circ Res 114(4): 730-737.

Pollak N, Niere M, Ziegler M. NAD kinase levels control the NADPH concentration in human cells. J Biol Chem. 2007;282(46):33562-71.

Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.

Powers, S. K. and M. J. Jackson (2008). “Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.” Physiol Rev 88(4): 1243-1276.

Prasad G. Crystan, Structure of Aplysia ADP ribosyl cyclase, a homologue of the befuntional extozyme CD 38. 1996.

Predmore, B. L., D. J. Lefer and G. Gojon (2012). “Hydrogen sulfide in biochemistry and medicine.” Antioxid Redox Signal 17(1): 119-140.

Predmore, B. L., K. Kondo, S. Bhushan, M. A. Zlatopolsky, A. L. King, J. P. Aragon, D. B. Grinsfelder, M. E. Condit and D. J. Lefer (2012). “The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability.” Am J Physiol Heart Circ Physiol 302(11): H2410-2418.

Predmore, B. L., M. J. Alendy, K. I. Ahmed, C. Leeuwenburgh and D. Julian (2010). “The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction.” Age (Dordr) 32(4): 467-481.

Ramsey, K. M. and J. Bass (2009). “Obeying the clock yields benefits for metabolism.” Proc Natl Acad Sci U S A 106(11): 4069-4070.

Ramsey, K. M., J. Yoshino, C. S. Brace, D. Abrassart, Y. Kobayashi, B. Marcheva, H. K. Hong, J. L. Chong, E. D. Buhr, C. Lee, J. S. Takahashi, S. Imai and J. Bass (2009). “Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.” Science 324(5927): 651-654.

Ramsey, K. M., K. F. Mills, A. Satoh and S. Imai (2008). “Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.” Aging Cell 7(1): 78-88.

Ravussin, E., L. M. Redman, J. Rochon, S. K. Das, L. Fontana, W. E. Kraus, S. Romashkan, D. A. Williamson, S. N. Meydani, D. T. Villareal, S. R. Smith, R. I. Stein, T. M. Scott, T. M. Stewart, E. Saltzman, S. Klein, M. Bhapkar, C. K. Martin, C. H. Gilhooly, J. O. Holloszy, E. C. Hadley, S. B. Roberts and C. S. Group (2015). “A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.” J Gerontol A Biol Sci Med Sci 70(9): 1097-1104.

Reuben D. (2002) Peripheral Blood Markers of Inflammation Predict Mortality and Functional Decline in High-Functioning Community-Dwelling Older Persons.

Rey, G. and A. B. Reddy (2013). “Protein acetylation links the circadian clock to mitochondrial function.” Proc Natl Acad Sci U S A 110(9): 3210-3211.

Reynolds, L. M., J. R. Taylor, J. Ding, K. Lohman, C. Johnson, D. Siscovick, G. Burke, W. Post, S. Shea, D. R. Jacobs, Jr., H. Stunnenberg, S. B. Kritchevsky, I. Hoeschele, C. E. McCall, D. M. Herrington, R. P. Tracy and Y. Liu (2014). “Age-related variations in the methylome associated with gene expression in human monocytes and T cells.” Nat Commun 5: 5366.

Rickabaugh, T. M., R. M. Baxter, M. Sehl, J. S. Sinsheimer, P. M. Hultin, L. E. Hultin, A. Quach, O. Martinez-Maza, S. Horvath, E. Vilain and B. D. Jamieson (2015). “Acceleration of age-associated methylation patterns in HIV-1-infected adults.” PLoS One 10(3): e0119201.

idker P. Elevation of Tumor Necrosis Factor-a and Increased Risk of Recurrent Coronary Events After Myocardial Infarction. 2000.

Ridker P. Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men. 2000.

Roadmap Epigenomics, C., A. Kundaje, W. Meuleman, J. Ernst, M. Bilenky, A. Yen, A. Heravi-Moussavi, P. Kheradpour, Z. Zhang, J. Wang, M. J. Ziller, V. Amin, J. W. Whitaker, M. D. Schultz, L. D. Ward, A. Sarkar, G. Quon, R. S. Sandstrom, M. L. Eaton, Y. C. Wu, A. R. Pfenning, X. Wang, M. Claussnitzer, Y. Liu, C. Coarfa, R. A. Harris, N. Shoresh, C. B. Epstein, E. Gjoneska, D. Leung, W. Xie, R. D. Hawkins, R. Lister, C. Hong, P. Gascard, A. J. Mungall, R. Moore, E. Chuah, A. Tam, T. K. Canfield, R. S. Hansen, R. Kaul, P. J. Sabo, M. S. Bansal, A. Carles, J. R. Dixon, K. H. Farh, S. Feizi, R. Karlic, A. R. Kim, A. Kulkarni, D. Li, R. Lowdon, G. Elliott, T. R. Mercer, S. J. Neph, V. Onuchic, P. Polak, N. Rajagopal, P. Ray, R. C. Sallari, K. T. Siebenthall, N. A. Sinnott-Armstrong, M. Stevens, R. E. Thurman, J. Wu, B. Zhang, X. Zhou, A. E. Beaudet, L. A. Boyer, P. L. De Jager, P. J. Farnham, S. J. Fisher, D. Haussler, S. J. Jones, W. Li, M. A. Marra, M. T. McManus, S. Sunyaev, J. A. Thomson, T. D. Tlsty, L. H. Tsai, W. Wang, R. A. Waterland, M. Q. Zhang, L. H. Chadwick, B. E. Bernstein, J. F. Costello, J. R. Ecker, M. Hirst, A. Meissner, A. Milosavljevic, B. Ren, J. A. Stamatoyannopoulos, T. Wang and M. Kellis (2015). “Integrative analysis of 111 reference human epigenomes.” Nature 518(7539): 317-330.

Rose G, Dato S, Altomare K, Bellizzi D, Garasto S, Greco V, et al. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp Gerontol. 2003;38(10):1065-70.

Sahu, R. P., S. Batra and S. K. Srivastava (2009). “Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.” Br J Cancer 100(9): 1425-1433.

Sauve AA.  Schramm, V. (2002) Mechanism-Based Inhibitors of CD38: A Mammalian Cyclic ADP-Ribose Synthetase.

Sauve AA.  Munshi, C, Lee, HC, Schramm, V. (1998) The Reaction Mechanism for CD38. A Single Intermediate Is Responsible for Cyclization, Hydrolysis, and Base-Exchange Chemistries.

Schmeisser, K., J. Mansfeld, D. Kuhlow, S. Weimer, S. Priebe, I. Heiland, M. Birringer, M. Groth, A. Segref, Y. Kanfi, N. L. Price, S. Schmeisser, S. Schuster, A. F. Pfeiffer, R. Guthke, M. Platzer, T. Hoppe, H. Y. Cohen, K. Zarse, D. A. Sinclair and M. Ristow (2013). “Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.” Nat Chem Biol 9(11): 693-700.

Seshadri, S., A. Beiser, J. Selhub, P. F. Jacques, I. H. Rosenberg, R. B. D’Agostino, P. W. Wilson and P. A. Wolf (2002). “Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease.” N Engl J Med 346(7): 476-483.

Shang, Z., C. Lu, S. Chen, L. Hua and R. Qian (2012). “Effect of H(2)S on the circadian rhythm of mouse hepatocytes.” Lipids Health Dis 11: 23.

Sharma A, Diecke S, Zhang WY, Lan F, He C, Mordwinkin NM, et al. The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem. 2013;288(25):18439-47.

Shen J, Ma W, Liu Y. Deacetylase SIRT6 deaccelerates endothelial senescence. Cardiovasc Res. 2013;97(3):391-2.

Sies, H. (2014). “Role of metabolic H2O2 generation: redox signaling and oxidative stress.” J Biol Chem 289(13): 8735-8741.Signaling Related to C a r d i a c Sarcoplasmic Reticulum: S u p e r o x i d e A n i o n Radical-Triggered C a 2 + Release. 2000.

Signaling Related to C a r d i a c Sarcoplasmic Reticulum: S u p e r o x i d e A n i o n Radical-Triggered C a 2 + Release. 2000.

Sodha, N. R., R. T. Clements, J. Feng, Y. Liu, C. Bianchi, E. M. Horvath, C. Szabo and F. W. Sellke (2008). “The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury.” Eur J Cardiothorac Surg 33(5): 906-913.

Sohal RS, Orr WC. The redox stress hypothesis of aging. Free Radic Biol Med. 2012;52(3):539-55.

Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010;143(5):802-12.

Stefanson, A. L. and M. Bakovic (2014). “Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals.” Nutrients 6(9): 3777-3801.

Suh JH, Wang H, Liu RM, Liu J, Hagen TM. (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys. 2004;423(1):126-35.

Sun L. Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. 2003.

Suzuki T, Motohashi H, Yamamoto M. Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci. 2013;34(6):340-6.

Suzuki T. Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels. 2013.

Szabo, C., C. Coletta, C. Chao, K. Modis, B. Szczesny, A. Papapetropoulos and M. R. Hellmich (2013). “Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.” Proc Natl Acad Sci U S A 110(30): 12474-12479.

Szilard L. ON THE NATURE OF THE AGING PROCESS. 1959.

Taaffe D. Cross-sectional and Prospective Relationships of Interleukin-6 and C-Reactive Protein With Physical Performance in Elderly Persons: MacArthur Studies of Successful Aging. 2000.

Tachibana, T., S. Okazaki, A. Murayama, A. Naganuma, A. Nomoto and S. Kuge (2009). “A major peroxiredoxin-induced activation of Yap1 transcription factor is mediated by reduction-sensitive disulfide bonds and reveals a low level of transcriptional activation.” J Biol Chem 284(7): 4464-4472.

Takeuchi K, Kita K, Hayashi S, Aihara E. Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide. Pharmacol Ther. 2011;130(1):59-70.

Takeuchi K. MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE 4 IS ESSSENTIAL FOR CHOLINERGIC STIMULATION OF DUODENAL BICARBONATE SECRETION IN MICE – RELATIONSHIP TO D CELL/SOMATOSTATIN. 2015.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, et al. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014;19(4):605-17.

Tang, X. Q., R. Q. Chen, Y. K. Ren, P. D. Soldato, A. Sparatore, Y. Y. Zhuang, H. R. Fang and C. Y. Wang (2011). “ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function.” Med Gas Res 1(1): 20.

Tirumurugaan KG, Kang BN, Panettieri RA, Foster DN, Walseth TF, Kannan MS. Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone. Respir Res. 2008;9:26.

Tocmo, R., D. Liang, Y. Lin and D. Huang (2015). “Chemical and biochemical mechanisms underlying the cardioprotective roles of dietary organopolysulfides.” Front Nutr 2: 1.

Tomczyk, S., K. Fischer, S. Austad and B. Galliot (2015). “, a powerful model for aging studies.” Invertebr Reprod Dev 59(sup1): 11-16.

Tu, H. C., D. Ren, G. X. Wang, D. Y. Chen, T. D. Westergard, H. Kim, S. Sasagawa, J. J. Hsieh and E. H. Cheng (2009). “The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage.” Proc Natl Acad Sci U S A 106(4): 1093-1098.

Tyagi, N., K. S. Moshal, U. Sen, T. P. Vacek, M. Kumar, W. M. Hughes, Jr., S. Kundu and S. C. Tyagi (2009). “H2S protects against methionine-induced oxidative stress in brain endothelial cells.” Antioxid Redox Signal 11(1): 25-33.

van den Bogaard EH, Bergboer JG, Vonk-Bergers M, van Vlijmen-Willems IM, Hato SV, van der Valk PG, et al. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest. 2013;123(2):917-27.

Vanyushin, B. F. (2005). “Enzymatic DNA methylation is an epigenetic control for genetic functions of the cell.” Biochemistry (Mosc) 70(5): 488-499.

Varadhan R, Yao W, Matteini A, Beamer BA, Xue QL, Yang H, et al. Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(2):165-73.

Wakabayashi, N., A. T. Dinkova-Kostova, W. D. Holtzclaw, M. I. Kang, A. Kobayashi, M. Yamamoto, T. W. Kensler and P. Talalay (2004). “Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.” Proc Natl Acad Sci U S A 101(7): 2040-2045.

Wallace JL. Physiological and Pathophysiological Roles of Hydrogen Sulfide in the Gastrointestinal Tract. 2010.

Wallace, J. L. and R. Wang (2015). “Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter.” Nat Rev Drug Discov 14(5): 329-345.

Wang F, Li Y, Cao Y, Li C. Zinc might prevent heat-induced hepatic injury by activating the Nrf2-antioxidant in mice. Biol Trace Elem Res. 2015;165(1):86-95.

Wang Z, Zhang L, Liang Y, Zhang C, Xu Z, Zhang L, et al. Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin. Sci Rep. 2015;5:12012.

Wang, J., S. Zhang, Y. Wang, L. Chen and X. S. Zhang (2009). “Disease-aging network reveals significant roles of aging genes in connecting genetic diseases.” PLoS Comput Biol 5(9): e1000521.

Wang, R. (2002). “Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter?” FASEB J 16(13): 1792-1798.

Wenger, Y. and B. Galliot (2013). “RNAseq versus genome-predicted transcriptomes: a large population of novel transcripts identified in an Illumina-454 Hydra transcriptome.” BMC Genomics 14: 204.

Whiteman, M. and P. K. Moore (2009). “Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?” J Cell Mol Med 13(3): 488-507.

Wilson HL, Dipp M, Thomas JM, Lad C, Galione A, Evans AM. Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction. J Biol Chem. 2001;276(14):11180-8.

Wintner, E. A., T. L. Deckwerth, W. Langston, A. Bengtsson, D. Leviten, P. Hill, M. A. Insko, R. Dumpit, E. VandenEkart, C. F. Toombs and C. Szabo (2010). “A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood.” Br J Pharmacol 160(4): 941-957.

Wu Y, Chen L, Wang Y, Li W, Lin Y, Yu D, et al. Overexpression of Sirtuin 6 suppresses cellular senescence and NF-kappaB mediated inflammatory responses in osteoarthritis development. Sci Rep. 2015;5:17602.

Wu, C. C. and S. B. Bratton (2013). “Regulation of the intrinsic apoptosis pathway by reactive oxygen species.” Antioxid Redox Signal 19(6): 546-558.

Wu, D., Q. Hu, X. Liu, L. Pan, Q. Xiong and Y. Z. Zhu (2015). “Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes.” Nitric Oxide 46: 204-212.

Wu, L. and R. Derynck (2009). “Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.” Dev Cell 17(1): 35-48.

Xu, Z., G. Prathapasinghe, N. Wu, S. Y. Hwang, Y. L. Siow and K. O (2009). “Ischemia-reperfusion reduces cystathionine-beta-synthase-mediated hydrogen sulfide generation in the kidney.” Am J Physiol Renal Physiol 297(1): F27-35.

Yang, G., L. Wu, B. Jiang, W. Yang, J. Qi, K. Cao, Q. Meng, A. K. Mustafa, W. Mu, S. Zhang, S. H. Snyder and R. Wang (2008). “H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.” Science 322(5901): 587-590.

Yao, L. L., X. W. Huang, Y. G. Wang, Y. X. Cao, C. C. Zhang and Y. C. Zhu (2010). “Hydrogen sulfide protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by preventing GSK-3beta-dependent opening of mPTP.” Am J Physiol Heart Circ Physiol 298(5): H1310-1319.

Yonezawa D, Sekiguchi F, Miyamoto M, Taniguchi E, Honjo M, Masuko T, et al. A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium. Toxicology. 2007;241(1-2):11-8.

Yong, Q. C., S. W. Lee, C. S. Foo, K. L. Neo, X. Chen and J. S. Bian (2008). “Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning.” Am J Physiol Heart Circ Physiol 295(3): H1330-H1340.

Yoshino, J. and S. Imai (2013). “Accurate measurement of nicotinamide adenine dinucleotide (NAD(+)) with high-performance liquid chromatography.” Methods Mol Biol 1077: 203-215.

Yu, Q., Y. V. Katlinskaya, C. J. Carbone, B. Zhao, K. V. Katlinski, H. Zheng, M. Guha, N. Li, Q. Chen, T. Yang, C. J. Lengner, R. A. Greenberg, F. B. Johnson and S. Y. Fuchs (2015). “DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.” Cell Rep 11(5): 785-797.

Yudoh K, Karasawa R, Ishikawa J. Age-related Decrease of Sirtuin 2 Protein in Human Peripheral Blood Mononuclear Cells. Curr Aging Sci. 2015;8(3):256-8.

Zee, R. S., C. B. Yoo, D. R. Pimentel, D. H. Perlman, J. R. Burgoyne, X. Hou, M. E. McComb, C. E. Costello, R. A. Cohen and M. M. Bachschmid (2010). “Redox regulation of sirtuin-1 by S-glutathiolation.” Antioxid Redox Signal 13(7): 1023-1032.

Zhang AY, Yi F, Teggatz EG, Zou AP, Li PL. Enhanced production and action of cyclic ADP-ribose during oxidative stress in small bovine coronary arterial smooth muscle. Microvasc Res. 2004;67(2):159-67.

Zhao, W., J. Zhang, Y. Lu and R. Wang (2001). “The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener.” EMBO J 20(21): 6008-6016.

Zhao, Y., S. Bhushan, C. Yang, H. Otsuka, J. D. Stein, A. Pacheco, B. Peng, N. O. Devarie-Baez, H. C. Aguilar, D. J. Lefer and M. Xian (2013). “Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.” ACS Chem Biol 8(6): 1283-1290.

Zhou T, Kurnasov O, Tomchick DR, Binns DD, Grishin NV, Marquez VE, et al. Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. J Biol Chem. 2002;277(15):13148-54.

© Copyright 2017 Egaceutical Corporation